Microbiota and autoimmunity

Microbiota and autoimmunity.

The commensal microbiota affects many aspects of mammalian health including control of the immune system to such a extent that a "commensalocentric" view of the maintenance of overall health could be suggested. Autoimmunity is a case of mistaken identity: The immune system reacts to self-tissues and cells as if they were pathogens. Autoimmune reactions can be both advanced or blocked by the com...

Microbiota at the crossroads of autoimmunity.

Autoimmune diseases have a multifactorial etiology including genetic and environmental factors. Recently, there has been increased appreciation of the critical involvement of the microbiota in the pathogenesis of autoimmunity, although in many cases, the cause and the consequence are not easy to distinguish. Here, we suggest that many of the known cues affecting the function of the immune syste...

The lung microbiota in early rheumatoid arthritis and autoimmunity

BACKGROUND Airway abnormalities and lung tissue citrullination are found in both rheumatoid arthritis (RA) patients and individuals at-risk for disease development. This suggests the possibility that the lung could be a site of autoimmunity generation in RA, perhaps in response to microbiota changes. We therefore sought to test whether the RA lung microbiome contains distinct taxonomic features...

Gut Microbiota and Neuropsychiatric Disorders

Alterations in Intestinal Microbiota Correlate with Susceptibility to Type 1 Diabetes Running title: Gut microbiota in subjects with islet autoimmunity